Fear, Memory and the Brain Joseph E. LeDoux, PhD

Point your mouse over the words "Slide 19, Slide 20, Slide 21, etc" to view the slides.

	Slide 19: Amygdala might be involved in pathological fears in humans by being over-reactive or over-sensitive. Click for: AUDIO
	Slide 20: The amygdala's connections with the hippocampus and the medial prefrontal cortex may contribute to pathological fear responses: hippo. damage produces loss of context; MPC damage leads to problems in fear regulation. Click for: AUDIO
	Slide 21: The stress hormone cortisol impairs hippocampus and MPC function, while enhancing amygdala function. Click for: AUDIO
	Slide 22: Given the effects of cortisol, one can see how pathological fear can come about: impairing hippoocampus leads to loss of contextual meaning of threats, impairing MPC leads to overreactivity, and activation of amygdala leads to overeactivity. All of these are common features of anxiety disorders. Click for: AUDIO
	Slide 23: Hopefully basic science studies can reveal not only how fear works in the brain, but also how it can be treated. Click for: AUDIO
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