Web  Lecture - McEwen - page 4 - slides # 19-24
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"Sex, Stress and the Hippocampus: Receptors, Intracellular Mechanisms and Synaptic Plasticity"
Bruce S. McEwen, PhD

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Slide 19: Some human disorders where   hippocampus is atrophied. Elevated glucocorticoid levels are implicated.
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Slide 20: In treatment of Cushing's disease, decreasing cortisol levels are correlated with increased hippocampal volume. i.e. hippo. atrophy is reversible.
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Slide 21: Depressive illness shows many of the same bodily changes as are seen in Cushing's disease.
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Slide 22: Hippocampal atrophy is correlated with length of depressive illness.
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Slide 23: In depression, hippo. atrophy may be accompanied by lesions or other damage. Autopsy data is needed to confirm this. Not clear whether this atrophy can be reversed.
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Slide 24: Possible causes of hippo. atrophy.
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