Approaches to reducing neuronal death after acute brain ischemia Dennis W. Choi, MD, PhD

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	Slide 7: Two forms of excitotoxicity are distinguished by differences in time course and pharmacology. Click for: AUDIO
	Slide 8: Glutamate toxicity also likely contributes to brain damage associated with other acute insults. Click for: AUDIO
	Slide 9: In vitro studies implicated glutamate neurotoxicity in hypoxoic  ischemic brain damage. Click for: AUDIO
	Slide 10: In vitro effects of oxygen and glucose removal are similar to what is seen when glutamate is added to bathing media. Click for: AUDIO
	Slide 11: Administration of NMDA antagonist in vivo reduces infarction in a rat model. Click for: AUDIO
	Slide 12: Other neuroprotective approaches may target events downstream of glutamate receptor over-activation. Click for: AUDIO
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